abstract：:We have recently shown that a heat treatment of a murine target cell line, WEHI 164, induces resistance to lysis mediated by tumour necrosis factors alpha (TNF-alpha) and beta (TNF-beta). In the present study the effect of the heat shock of target cells on cytotoxicity mediated by natural killer cells (NK cells), lymp...

journal_title：Scandinavian journal of immunology

authors： Jäättelä M

更新日期：1990-02-01 00:00:00

abstract：:Plasma and serum samples from a patient with homozygous C2 deficiency and severe systemic lupus erythematosus who responded with full clinical remission after plasma infusions were examined for immune complexes (IC), C3 activation products, and the terminal complement complex (TCC). Plasma contained large amounts of C...

journal_title：Scandinavian journal of immunology

authors： Garred P,Mollnes TE,Thorsteinsson L,Erlendsson K,Steinsson K

更新日期：1990-01-01 00:00:00

abstract：:The purpose of this study was to investigate interleukin 2 (IL-2) and gamma interferon (IFN-gamma) production by purified CD4+ and CD8+ cells isolated from peripheral blood (PB) and synovial fluid (SF) of patients with rheumatoid arthritis (RA) and other inflammatory arthritides (non-RA). CD4+ and CD8+ cells were sele...

journal_title：Scandinavian journal of immunology

authors： Hovdenes J,Gaudernack G,Kvien TK,Hovdenes AB,Egeland T

更新日期：1989-11-01 00:00:00

abstract：:Active chloride (Cl-) secretion by intestinal crypt enterocytes is the central pathophysiological disturbance in most cases of acute diarrhoea. We examined monolayers of the human intestinal cell line T84 mounted in Ussing chambers to see whether the T-cell lymphokine gamma interferon (IFN-gamma) might affect the Cl- ...

journal_title：Scandinavian journal of immunology

authors： Holmgren J,Fryklund J,Larsson H

更新日期：1989-10-01 00:00:00

abstract：:Histamine was shown to suppress the in vitro generation of secondary syngeneic tumour-specific Ly-2+, L3T4- cytotoxic T cells from Ly-2+, L3T4- precursor cells. The sensitivity of the spleen cells from P815X2 mastocytoma-bearing DBA/2 mice to histamine-induced suppression changed during tumour progression; by the time...

journal_title：Scandinavian journal of immunology

authors： Laatikainen A

更新日期：1989-10-01 00:00:00

abstract：:In a previous study we observed that after in vitro treatment with indomethacin, lymphocyte response to phytohaemagglutinin (PHA) in primary biliary cirrhosis (PBC) patients was higher than that of controls. We know that indomethacin also inhibits prostanoid production, and thus in the present work we directly measure...

journal_title：Scandinavian journal of immunology

authors： Chiricolo M,Lenzi M,Bianchi F,Franceschi C,Bartolini G,Orlandi M,Tomasi V,Licastro F

更新日期：1989-09-01 00:00:00

abstract：:The ability of 17 monoclonal antibodies (MoAb) against measles virus haemagglutinin (MV-H) to bind to 10 selected MV-H-specific synthetic peptides was tested in an enzyme immunoassay (EIA). Three peptides representing residues 126-135 (close to the NH2 terminus), 309-318 (middle), and 587-596 (C-terminal) reacted with...

journal_title：Scandinavian journal of immunology

authors： Mäkelä MJ,Salmi AA,Norrby E,Wild TF

更新日期：1989-08-01 00:00:00

abstract：:The restriction fragment length polymorphism of the human tumour necrosis factor (TNF alpha) region was investigated by means of 20 different restriction enzymes and a human TNF alpha cDNA probe. Only one of the enzymes, NcoI, revealed a polymorphic pattern consisting of fragments of 10.5 and 5.5 kb, which behaved as ...

journal_title：Scandinavian journal of immunology

authors： Fugger L,Morling N,Ryder LP,Platz P,Georgsen J,Jakobsen BK,Svejgaard A,Dalhoff K,Ranek L

更新日期：1989-08-01 00:00:00

abstract：:Phagocytosis of Staphylococcus aureus by human polymorphonuclear leucocytes (PMN) on the surface of endothelial cells is accompanied by adherence of the PMN to the endothelial surface and detachment of the endothelial cells from the culture monolayer. We studied the role of the leucocyte adherence-related glycoprotein...

journal_title：Scandinavian journal of immunology

authors： Vandenbroucke-Grauls CM,Thijssen HM,Tetteroo PA,Rozemuller E,Verhoef J

更新日期：1989-07-01 00:00:00

abstract：:To delineate accurately the IgG subclass distribution of thyroid auto-antibodies, sera from nine patients with Hashimoto's thyroiditis were fractionated into IgG subclasses by complete depletion of the other IgG subclasses on affinity columns. All IgG subclass fractions contained thyroglobulin and microsomal (or thyro...

journal_title：Scandinavian journal of immunology

authors： Weetman AP,Black CM,Cohen SB,Tomlinson R,Banga JP,Reimer CB

更新日期：1989-07-01 00:00:00

abstract：:Natural killer (NK) cells form part of the vertebrate defence against viruses and tumours, but show only limited specificity. The molecule(s) recognized by NK cells on target cells are at present unknown. Major histocompatibility complex (MHC) class I antigen concentration on target cells is inversely correlated with ...

journal_title：Scandinavian journal of immunology

authors： Müllbacher A,King NJ

更新日期：1989-07-01 00:00:00

abstract：:Antigen fragments, biologically degraded by antigen-presenting cells (APC), combine with Ia positive moieties (IPM) to stimulate antigen-specific T lymphocyte lines. The main objective of this study was to evaluate whether this interaction was determined by the major histocompatibility complex (MHC) genotype of the AP...

journal_title：Scandinavian journal of immunology

authors： Friedman A,Lider O,Beraud E,Cohen IR

更新日期：1989-06-01 00:00:00

abstract：:The short-term incubation of rat thymocytes with 12-O-tetradecanoylphorbol-13-acetate (TPA) resulted in a significant increase in sialyltransferase (S-T) activity and a decrease in terminal deoxyribonucleotidyl transferase (TdT) activity. The ratio of peanut agglutinin (PNA)-positive cells and of TdT-positive cells in...

journal_title：Scandinavian journal of immunology

authors： Sasaki R,Takaku F,Miura Y

更新日期：1989-04-01 00:00:00

abstract：:Saliva was collected from 57 infants aged 6 weeks to 2.5 years and the molecular form of IgA was studied by centrifugation on sucrose density gradients. Two distinct populations were identified. Seventy-two per cent of the children had secretory IgA in their salivary secretions, while 28% had a molecular form correspo...

journal_title：Scandinavian journal of immunology

authors： Cripps AW,Gleeson M,Clancy RL

更新日期：1989-03-01 00:00:00

abstract：:Rat monoclonal antibodies directed against the BALB/c myeloma protein M315 (alpha,lambda 2) are described. 9A8 (IgG1) binds the V domain of lambda 2 and cross-reacts with lambda 1 and lambda 3 chains. 2B6 (IgG2a) is directed to the C domain of lambda 2 and cross-reacts with C lambda 3. The antibodies bind isolated cha...

journal_title：Scandinavian journal of immunology

authors： Bogen B

更新日期：1989-03-01 00:00:00

abstract：:The effect of trypsin on mouse spleen cells and enriched B cells, added alone or together with lipopolysaccharide (LPS), was investigated. With trypsin, proliferation in serum free spleen cell cultures was 2-6 times greater than the background using cells from LPS responder strains, and 2-4 times the background with c...

journal_title：Scandinavian journal of immunology

authors： Cardell S,Möller G

更新日期：1989-02-01 00:00:00

abstract：:The relationship of velocity of blood flow to density and microanatomical distribution of inflammatory cells in the dermis was studied in 20 human tuberculin tests. Most positive reactions showed maximal blood flow velocities (measured as red blood cell (RBC) flux) at the centre of the reaction, but the two most inten...

journal_title：Scandinavian journal of immunology

authors： Swanson Beck J,Gibbs JH,Potts RC,Jawad ES,Kardjito T,Spence VA,Grange JM

更新日期：1989-01-01 00:00:00

abstract：:The main object of this study was to see whether or not chromatin constituents are present in cell membranes. The binding of antinuclear antibodies (ANA) to plasma membranes of leucocytes was studied by using autoantibodies and induced antibodies to different histones and histone peptides, and autoantibodies to double...

journal_title：Scandinavian journal of immunology

authors： Rekvig OP

更新日期：1989-01-01 00:00:00

abstract：:The avidity of breast milk IgA antibody was studied with the aid of thiocyanate elution of antibody from solid-phase bound E.coli polysaccharides and diphtheria toxoid. The relative avidity index for each sample was determined by the molarity of thiocyanate required to elute 50% of the bound IgA antibody under conditi...

journal_title：Scandinavian journal of immunology

authors： Roberton DM,Carlsson B,Coffman K,Hahn-Zoric M,Jalil F,Jones C,Hanson LA

更新日期：1988-12-01 00:00:00

abstract：:To determine whether psoriatic keratinocytes differ from normal keratinocytes in their response to gamma interferon, epidermal cell suspensions from normal and from lesional and uninvolved psoriatic skin were cultured in the presence of gamma interferon and the induction of HLA-DR expression and inhibition of cell gro...

journal_title：Scandinavian journal of immunology

authors： Baker BS,Powles AV,Valdimarsson H,Fry L

更新日期：1988-12-01 00:00:00

abstract：:Purified human amyloid protein A (AA) or serum amyloid protein A (SAA) was incubated with normal human high-density lipoprotein (HDL). After ultracentrifugation the amount of AA or SAA associated with HDL was measured. It was found that the binding capacity of HDL for SAA was higher than that for AA. Incubation of the...

journal_title：Scandinavian journal of immunology

authors： Husebekk A,Skogen B,Husby G

更新日期：1988-12-01 00:00:00

abstract：:Human peripheral blood lymphocytes (PBL) were activated with K46M, a m mitogenic monoclonal antibody against La-reactive T lymphocyte surface structures. The cultures were expanded in the presence of interleukin 2 (IL-2). After 1 month of culture, the activated T cells were cloned by limiting dilution at 0.5 cells/wel...

journal_title：Scandinavian journal of immunology

authors： Berzins T,Vargas-Cortes M,Axelsson B,Hammarström ML,Hammarström S,Perlmann P

更新日期：1988-11-01 00:00:00

abstract：:The activation of resting T cells to interleukin 2 (IL-2) production and DNA synthesis via Ti-CD3 is dependent on accessory cells (AC). Using positively selected, resting T cells activated with particle-bound anti-CD3, we investigated the ability of various cell lines to function as AC. We found that cell lines able t...

journal_title：Scandinavian journal of immunology

authors： Halvorsen R,Leivestad T,Gaudernack G,Thorsby E

更新日期：1988-09-01 00:00:00

abstract：:Secretory component (SC) acts as a receptor for polymeric IgA (pIgA) and pIgM on the basolateral face of secretory epithelia. This study showed that both the production and surface membrane expression of SC were additively up-regulated by tumour necrosis factor-alpha (TNF) and gamma interferon (IFN-gamma) in a human c...

journal_title：Scandinavian journal of immunology

authors： Kvale D,Brandtzaeg P,Løvhaug D

更新日期：1988-09-01 00:00:00

abstract：:The predominant selection of CRI-A-bearing antibodies during the anti-arsonate (ARS) response of A/J mice has been used as a model to analyse the mechanism involved in the process of clonal selection and establishment of predominance. In order to assess the importance of the affinity and adaptability of CRI-A clones i...

journal_title：Scandinavian journal of immunology

authors： Gaya A,Alsinet E,Freixas M,Vives J

更新日期：1988-09-01 00:00:00

abstract：:We have previously shown that various benign and malignant natural killer (NK)-resistant monolayer cells inhibit endogenous human NK activity, probably by reducing the secretion of cytotoxic factors from the effector cells. The nature of the molecules responsible for the inhibition has been unclear. In this study we s...

journal_title：Scandinavian journal of immunology

authors： Heiskala MK,Stenman UH,Koivunen E,Carpén O,Saksela E,Timonen T

更新日期：1988-07-01 00:00:00

abstract：:Heterogeneity in antigen recognition of an alloreactive helper T-cell line was studied by repeated limiting dilution cloning. Analysis of the fine specificities of these clones showed that the gain of reactivity to new antigens by the T-cell line included the generation of non-cross-reactive T cells specific to new ma...

journal_title：Scandinavian journal of immunology

authors： Rajasekar R,Andersson J,Leanderson T

更新日期：1988-06-01 00:00:00

abstract：:The ability of different subpopulations of blood mononuclear cells to serve as accessory cells in the activation of CD4+ and CD8+ T cells via Ti-CD3 or with phytohaemagglutinin (PHA) was studied. Pure CD4+ or CD8+ T cells did not respond to particle-bound anti-CD3 monoclonal antibodies (MoAb) or PHA, whereas responses...

journal_title：Scandinavian journal of immunology

authors： Halvorsen R,Leivestad T,Gaudernack G,Thorsby E

更新日期：1988-05-01 00:00:00

abstract：:In the context of ex vivo T cell elimination from bone marrow, the anti-T cell cytotoxic potential of immunotoxins (IT) prepared by conjugation of the monoclonal antibodies (MoAb) WT32 (CD3), T101 (CD5), and WT1 (CD7) to ricin A chain was evaluated. The cytotoxicity of IT was based on protein synthesis inhibition in h...

journal_title：Scandinavian journal of immunology

authors： Preijers FW,Tax WJ,Wessels JM,Capel PJ,De Witte T,Haanen C

更新日期：1988-05-01 00:00:00

abstract：:To examine the possible relationship between the cells mediating resistance to tumour cells and those mediating rejection of foreign bone marrow transplants (BMT), the effect of tumour-bearing on BMT rejection has been measured by means of the spleen colony assay. Moderate doses (less than 5.0 X 10(6] of bone marrow c...

journal_title：Scandinavian journal of immunology

authors： Miller SC,Nguyen D,Bird IA

更新日期：1988-04-01 00:00:00

abstract：:F protein is of unknown function and found principally in the liver, with smaller amounts detectable by gel diffusion and immunostaining in kidney and brain. By taking advantage of a newly developed radioimmunoassay, capable of detecting down to 1 ng ml-1 of F protein, the organ distribution of this molecule in the mo...

journal_title：Scandinavian journal of immunology

authors： Griffiths JA,Oliveira DB

更新日期：1988-03-01 00:00:00

abstract：:L929, 3T12-3, B16, 3LL, and YAC1 cells with cytostatic factor (CF)-inducing activity from Lactobacillus casei-elicited murine peritoneal macrophages (LCEPM) were susceptible to the cytostatic activity of LCEPM and to LCEPM-produced CF, but L1210, P388D1, and Colon 26 cells, which have no CF-inducing activity, were res...

journal_title：Scandinavian journal of immunology

authors： Hashimoto S,Nagaoka M,Yokokura T,Mutai M

更新日期：1988-03-01 00:00:00

abstract：:The lectins from Datura stramonium, Lycopersicon esculentum, and Solanum tuberosum are structurally related and possess a similar carbohydrate specificity, yet the Datura lectin is mitogenic for human lymphocytes while the other two are not. However, the Datura lectin was found to antagonize blast transformation induc...

journal_title：Scandinavian journal of immunology

authors： McCurrach PM,Kilpatrick DC

更新日期：1988-01-01 00:00:00

abstract：:A method of isolation has been developed to purify mast cells from human lung tissue. The purification steps are: (1) dispersion of human lung tissue in single-cell suspensions by enzymatic digestion, (2) partial purification by counterflow centrifugal elutriation, (3) Percoll gradient centrifugation, and (4) enrichme...

journal_title：Scandinavian journal of immunology

authors： van Overveld FJ,Terpstra GK,Bruijnzeel PL,Raaijmakers JA,Kreukniet J

更新日期：1988-01-01 00:00:00

abstract：:The cloned murine cell line BK-BI-2.6.C6 has previously been shown to exhibit T cell characteristics, to synthesize and express MHC class II molecules, and to present protein antigens to antigen-dependent T cell clones. As a more definitive proof of the T-cell nature of these cells, transcripts of the rearranged T cel...

journal_title：Scandinavian journal of immunology

authors： Reske-Kunz AB,Rück G,Steinlein P,Reske K

更新日期：1988-01-01 00:00:00

abstract：:The homogenates of amyloid-laden spleens prepared from CBA mice were analysed by SDS-PAGE and immunoblotting employing rat anti-murine monoclonal antibody, MSA 4-26. The results showed that the precursor of amyloid A protein (AA), serum amyloid A protein 2 (SAA2), and SAA intermediates with molecular weights of 10,000...

journal_title：Scandinavian journal of immunology

authors： Shiroo M,Kawahara E,Nakanishi I,Migita S

更新日期：1987-12-01 00:00:00

abstract：:Thirty-two mycobacterial components were detected by antibodies contained in leprosy patients' sera across the clinical spectrum and rabbit anti-M. leprae hyperimmune sera by western blot analysis of armadillo-derived M. leprae antigen preparations. Sera of borderline tuberculoid patients were found to contain antibod...

journal_title：Scandinavian journal of immunology

authors： Ehrenberg JP,Gebre N

更新日期：1987-12-01 00:00:00

abstract：:The structural characteristics of a human plasma protein analogous to bovine conglutinin were studied. The protein was previously found to bind to complement-reacted IgG in a calcium-dependent and N-acetyl-D-glucosamine-inhibitable manner and it further shows cross-reactivity with anti-bovine conglutinin antibody. By ...

journal_title：Scandinavian journal of immunology

authors： Thiel S,Baatrup G,Friis-Christiansen P,Svehag SE,Jensenius JC

更新日期：1987-11-01 00:00:00

abstract：:The binding of 125I-labelled bovine serum albumin (BSA)-anti-BSA immune complexes (IC) to Raji cells and polymorphonuclear (PMN) cells in vitro was studied. The IC were reacted for 1 h at 37 degrees C with normal human serum (NHS) diluted 1:2 in the presence or absence of human erythrocytes (E) before presentation for...

journal_title：Scandinavian journal of immunology

authors： Rasmussen JM,Jepsen HH,Svehag SE

更新日期：1987-10-01 00:00:00

abstract：:Administration of cyclophosphamide (Cy: 150 mg/kg i.p.) to rats 48 h before immunization with a T-dependent antigen (ovalbumin) resulted in a striking absolute eosinophilia in blood, bone marrow, and secondary lymphoid organs after 10 to 14 days. This eosinophilia was preceded by a significant increase in the W3/25+/O...

journal_title：Scandinavian journal of immunology

authors： Mathie IH,Sewell HF,Thomson AW

更新日期：1987-10-01 00:00:00